Axel Tuanzebe's move to Napoli is set to kick start a January exodus at Manchester United with 17 players 'unhappy' at Old Trafford.
Mirror Football reported that 11 players have made it clear they want to leave Manchester within the coming months, with claims a further six are looking for a move elsewhere.
13 of the 17 individuals have been named with Anthony Martial, Paul Pogba, Jesse Lingard, Edinson Cavani, Juan Mata, Donny van de Beek, Dean Henderson, Eric Bailly, Phil Jones, Nemanja Matic, Fred, Diogo Dalot and Tuanzebe all unsettled at the club.
Tuanzebe is now the first disgruntled player to have his wish granted as he joined Napoli loan until the end of the season.
And his departure could get the ball rolling with many others expected to follow suit in January or in the summer.
Cavani, Pogba and Lingard are all out of contact at the end of the season and, as it stands, are set to leave United as a free agent unless they sign a new deal.
But Rangnick is willing to let their contracts wind down as the interim boss insists the trio are going nowhere in the current window.
Meanwhile, United legend Lou Macari has urged Rangnick to "kick out" those causing disorder behind the scenes.
Speaking on MUTV, per the Daily Mail, he told "Anyone kicking off in the dressing room, kick them out of the club. Get rid of them and I'm talking about the players doing that by the way.
"70,000 United supporters can't be wrong every week. These players have to start showing something.
"You've got the money and the lifestyle, what more do you want?
"I'm getting annoyed. I should be watching 11 happy players enjoying the game but I'm not detecting that.
"I don't see 11 happy players and they are second to most balls. Where's the aggression gone?"
Rangnick admitted there is a degree of unrest in the dressing room, but insisted the squad are still trying to adapt to his methods.
He said: "Only 10 outfield players can play, with three subs, so then you have quite a number of players who don't even play or are not even in the squad," Rangnick said.
"Those players are unhappy about the situation, it's obvious, clear. I tend to explain to players every two or three weeks why they are not playing and that's an issue in our team and other clubs."
The German added: "I'm sure they (the players) are listening and we showed that in the last games against Palace, Burnley and parts against Norwich and Newcastle, that they are trying to follow the advice I give them."